Materials for medicine
Associated Research Centres
First quantum measurement in living cell
A strong interdisciplinary collaboration among research teams led by Prof Hollenberg, Prof Caruso and Prof Mulvaney, demonstrated, for the first time, a quantum measurement in a living cell using nanodiamonds.
The research team led by Prof Caruso have also developed new ‘smart’ materials that can respond to changes in the cellular environment, that have low fouling properties, that self-assemble on surfaces and that have controlled degradation in the reducing environment of the cellular cytoplasm.
Multiple compartment compounds for improved drug retention
Loading and retaining low molecular weight compounds, such as anti-cancer drugs, is a significant challenge in nanomedical research. To this end, Prof Caruso’s group has incorporated multiple compartments such as liposomes and polymersomes to improve the retention of such drugs. The research team led by Prof Caruso have also demonstrated the loading, delivery and release of siRNA to prostate cancer cells.
Prof Caruso’s team took delivery of a ‘super-resolution’ optical microscope, which has double the resolution of conventional microscopes. This instrument represents a quantum shift in cellular imaging. It will enable researchers to image subcellular compartments, in real time, and will shed new light on how nanomaterials are processed by cells.Comparison of conventional microscopy (left) and super-resolution microscopy (right). The cell is stained so that the nucleus is blue, microtubules are green and the mitochondria are red. (A Johnston)